Scientists at the Cincinnati Stem Cell and Organoid Medicine Children's Center (CuSTOM) managed to expand the tissue of the esophagus from 300 to 800 micrometers in length during a study of the gene called Sox2 and the protein associated with this gene. Sox2 is a gene that plays a role in the development and maintenance of early embryo stem cells and various adult stem cells and is the basis of similar studies.
The research team used human, frog and mouse tissue cultures to detect the genetic and molecular pathways that Sox2 regulates during esophageal development. It was revealed that this tissue produced in laboratory environment has a high biochemical similarity with esophageal tissue taken from the patient.
Details of CuSTOM's work were published in Cell Stem Cell magazine. The study is intended to be used in the treatment of digestive system disorders and pave the way for new treatment methods in this area.
7 months ago